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Programa Preliminar - 59CBC
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Referencia Aprentador Autores Instituições Resumo
Maria José Alves Oliveira Maria José Alves Oliveira(1); Ademar Benévolo Lugão(2); Duclerc Fernandes Parra(3); IPEN-CNEN/USP(1); IPEN-CNEN/USP(2); IPEN-CNEN/USP(3); Abstract. It is estimated that there are about 300,00 products named biomaterials that are used in the health area. Although, they are widely used and have yet to be optimized for therapeutic application. In this context, the objective of this work was to develop hydrogels nanocomposites comprising for poly(vinyl alcohol-PVAl), glucantime, chitosan and synthetic clay Laponite RD; processed by gamma irradiation. To compare the behavior of drug release two systems were related: PVAl/chitosan/clay and PVAl/clay. The morphology of the nanocomposites hydrogel was determined by: X-ray diffraction, scanning electron microscopy (SEM), atomic force microscopy (AFM) and gel fraction. The release kinetics was analyzed at 37 °C for 48 hours. It was observed that the slower release of drug occurs in the delivery system composed by PVAl/chitosan/clay which can be related to intermolecular chitosan and PVAl crosslinking in addition to intramolecular chitosan crosslinking.
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